Aspirin availability

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PeteC
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Re: Aspirin availability

Post by PeteC » Tue Aug 22, 2017 4:31 pm

...."Aspirin at daily doses in excess of 300mg has a significant anti-platelet effect.".....

Is that correct or should it read less than 300mg? Above that < than 100mg is mentioned. Pete :cheers:
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oakdale160
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Re: Aspirin availability

Post by oakdale160 » Tue Aug 22, 2017 7:08 pm

Nereus, I had a Hip replacement done at B'grad and requested an epidural block rather than general anesthesia. They gave me a mild sleeping med at the same time so I dozed during the op. The other advantage was that they kept the block going for48h after surgery so I had no opioids or other pain meds.

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Re: Aspirin availability

Post by Nereus » Tue Aug 22, 2017 7:13 pm

Nereus, I had a Hip replacement done at B'grad and requested an epidural block rather than general anesthesia
.
Yes thanks, I am aware of the option.
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J.J.B.
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Re: Aspirin availability

Post by J.J.B. » Wed Aug 23, 2017 3:20 am

prcscct wrote:
Tue Aug 22, 2017 4:31 pm
...."Aspirin at daily doses in excess of 300mg has a significant anti-platelet effect.".....

Is that correct or should it read less than 300mg? Above that < than 100mg is mentioned. Pete :cheers:
It is correct and I apologise for any confusion caused. The anti-platelet effect is considered "significant" at doses above 300mg when compared in clinical trials - at that dose - with other products for that specific need, such as post-operative care. However, post hoc analyses of multiple, similar trials (a meta-analysis) revealed that patients suffered fewer cardiovascular events than expected in the general population with a similar risk profile, which was worthy of more study.

To test this finding, a lower dose (~75-100mg) was chosen to balance the known gastric side effects and trialled by a group of doctors (Swedish, if I remember correctly) on their "at risk" patients. Their pooled results from thousands of patients maintained a lower incidence of cardiovascular events overall with an acceptably small number of non-fatal, gastric bleeds. It was shown, therefore, that there is a dose-dependent relationship regarding aspirin's anti-platelet ("blood thinning") qualities whereby the more you take, the more profound it is. So if you are at low-to-moderate risk of experiencing a cardiovascular event and have a low risk of a gastrointestinal bleed, a low dose of aspirin is consider statistically better than nothing.

Medicine is littered with examples of such serendipitous discovery, from penicillin to sildenefil (Viagra). This is what empirical science is all about and there's probably a whole other thread about trials doctors can do on their patients vs. the regulations governing the Pharmaceutical industry.
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oakdale160
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Re: Aspirin availability

Post by oakdale160 » Wed Aug 23, 2017 10:28 am

The other reason for using a small dose is that with higher degrees of anti-coagulation the risk of hemorrhagic stroke (Bleeding into the brain tissue) is increased, whereas the risk of vascular stroke(Blood clot in an artery ) is decreased.

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